The aim of the present investigation is to formulate mouth dissolving tablets of Ketotifen Fumarate. Mouth dissolving tablets of Ketotifen Fumarate were prepared by two different techniques, Super disintegrant addition method and Effervescent formulation approach. Twelve formulations were prepared by Super disintegrant addition method using Sodium starch glycolate, Crospovidone, and Croscarmellose sodium as super disintegrants in combinations and at different concentrations. Another three batches were prepared by Effervescent formulation approach using Sodium bicarbonate and Citric acid (anhydrous) as effervescent agents. The prepared batches were evaluated for organoleptic properties, hardness, friability, weight variation, in vitro disintegration time, wetting time, in vitro drug release studies, and stability studies. Formulation prepared by Super disintegrant addition method using Sodium starch glycolate and Crospovidone in 3% and 5% w/w respectively, showed minimum time to disintegrate (18 sec.) and almost complete release of drug within 5 minutes. Finally it was concluded that MDT of Ketotifen Fumarate can be successfully formulated by both methods with improved patient compliance.
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